Physiological CSTC Circuit
Physiological Cognitive Control
OXIPASSIVE®
Glutamatergic Dysregulation in Obsessive-Compulsive Disorder
Supporting adjunctive neuro-redox homeostasis to target Cortico-Striato-Thalamo-Cortical (CSTC) pathway hyperactivity.
- Protect the Cell
- Restore Neuro-Redox Homeostasis
- Support Healthy CSTC Circuit Function
Executive Snapshot
Primary Biological Targets
- Glutamatergic Dysregulation
- Endogenous Glutathione
- Oxidative Neurobiological Stress
- Neuronal Resilience
- Neuroplasticity
1 - DISEASE BIOLOGY
CSTC Circuitry & Obsessive-Compulsive Loop
Physiological CSTC signaling coordinates behavioral inhibition and cognitive flexibility. In patients with OCD, chronic hyperactive glutamatergic signaling triggers a progressive neurobiological dysregulation cascade.
Hyperactive CSTC Circuit
⚠ Loss of Cognitive Control
L-Glutamine Dysregulation Pathway
↑ Glutamatergic Dysregulation
↓ Endogenous Glutathione
↓ Adaptive Neuroplasticity
Persistent Obsession-Compulsion Loop
2 - PATIENT SELECTION
Identifying the Candidate for Adjunctive Neuro-Redox Support
Appropriate Patient
- Moderate / Severe OCD
- Persistent OCD despite SSRI
- Partial Response
Clinical Setting
- ERP ± Pharmacotherapy
- Augmentation Candidate
Disease Status
- Residual Symptoms
- Functional Impairment
Clinical Role
Adjunctive Neuro-Redox Support
3 - NEURO-REDOX INTERVENTION IN CSTC CIRCUIT DYSFUNCTION
Intracellular Synergistic Synthesis Pathway
N-Acetyl-L-Cysteine (NAC)
- Support of physiological glutamate regulation
- Reduction of CSTC glutamatergic dysregulation
Reduction of oxidative neurobiological stress- Support of endogenous neuro-redox homeostasis
- Supports neural circuit recovery (CSTC function)
Glycine
- Supports physiological NMDA receptor function
- Supports adaptive neuroplasticity
- Supports cognitive flexibility
- Reinforces physiological CSTC signaling
- Supports neuronal resilience
Disease-Specific Biological Intervention Flow
Persistent CSTC Hyperactivity
Glutamatergic Dysregulation
Obsessions
Compulsions
Oxipassive® (NAC + Glycine)
Adaptive Neuroplasticity
Resilience
Cognitive Flexibility
Support of OCD Management
4 - CLINICAL POSITIONING
Adjunctive Neuro-Redox Support Boundaries
Biological Targets
- Glutamate
- Endogenous GSH
- Neuroplasticity
- Neuroinflammation
- CSTC Stability
Objectives
- Restore Glutamate Homeostasis
- Enhance Neuroplasticity
- Improve Neuronal Resilience
- Support Standard OCD Management
Clinical Boundaries
Adjunctive Neuro-Redox Platform integrated with standard OCD management.
5 - CLINICAL EVIDENCE DASHBOARD
Scientific Evidence & Literature Library
Evidence Timeline
2015Oliver et al.Review
2024Frontiers in PsychiatryRCTs
2026Communications MedicineRCT
MechanisticReviewSupportive
Clinical Pearl
Emerging evidence suggests that Neuro-Redox modulation may also contribute to improvement of oxidative stress associated anxiety symptoms
Human Neuro Clinical TrialPMID: 37366885
GlyNAC Synthesis Trial